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Effect on nucleotide metabolism in Leishmania mexicana axenic amastigotes treated with HD871-1, 10 μM for 36 h at 32 °C. Compared with untreated samples (DMSO, U), levels of dAMP, dTMP, dCMP and dGMP all climbed significantly during the course of treatment while the dinucleotides dADP and dTDP diminished (dGDP and dCDP were not identified). Orotate and dihydroorotate were both significantly diminished by treatment. y-axis is arbitrary units (AU).
