Figure 3.

Regional Plots for the Cytokine Network Association and Whole Blood and Immune Cell cis-eQTL Association Signals at the ABO, PCSK6, and SERPINE2 Locus

(A) The cytokine network GWAS signal (top) colocalizes with the whole blood cis-eQTLs signal for ABO (bottom) at the ABO locus on chromsome 9; (B) colocalizes with whole blood cis-eQTLs for PCSK6 expression (bottom) at the PCSK6 locus on chromosome 15; (C) colocalizes with the cis-eQTL signals for SERPINE2 expression in whole blood (middle), B cells (middle), and CD4⁺ T cells (bottom) at the SERPINE2 locus on chromosome 2. For each plot, the circles represent the -log₁₀ association p values (y axis) of SNPs plotted against their chromosomal position (x axis). The eQTL association plots show the lead cytokine network GWAS SNP tested in the colocalization analysis. The lead cytokine network GWAS SNP rs6722871 was not present in the B cell and CD4⁺ T cell eQTL dataset, instead, the next top GWAS SNP present in each of the eQTL dataset (rs861442, B cell; rs1438831, CD4⁺ T cell) is shown. For all regional plots, pairwise LD (r²) in the region is colored with respect to the lead cytokine network GWAS SNP. LD was calculated from the 1000 Genomes European population.