Table 2.

Susceptibility of a range of Leishmania species that cause CL against the experimental compounds (EC₅₀ in μM (95% confidence interval), n is experiment number) [LSHTM data].

	Compound ID	n	L. major	L. tropica	L. aethiopica	L. mexicana	L. panamensis	L. amazonensis	Cytotoxicity
Reference drugs	Amphotericin B	1	0.07 (0.06–0.09)	0.07 (0.07–0.08)	0.11 (0.10–0.13)	0.78 (1.6–0.20)	0.07 (0.07–0.08)
		2	0.03 (0.03–0.03)	0.34 (0.25–0.46)		0.08 (0.06–0.19)		0.13 (0.09–0.20)
	Miltefosine	1	28.89	35.20	36.10 (27.95–46.64)	11.21 (7.57–16.60)	21.33 (18.91–24.06)
		2	30.02	29.52		9.22 (7.35–11.56)		14.95 (12.08–18.49)
Nitroimidazoles	DNDI-0690	1	4.56 (2.73–7.62)	1.41 (1.29–1.53)	24.61	1.91 (1.60–2.31)	0.77	<1.11	>200
		2	7.94 (4.31–14.64)	2.38 (1.91–2.97)		< 1.11		<1.11
	DNDI-VL-2098	1	0.83 (0.62–1.12)	1.34 (1.17–1.54)		6.67 (5.75–7.73)			>200
	DNDI-8219	1	3.24 (1.09–9.69)	1.33 (0.95–1.85)	3.17 (2.84–3.53)	1.17 (0.82–1.68)	0.34 (0.31–0.37)	4.68	>200
		2	1.44 (1.30–1.60)	1.80 (1.66–1.96)		<1.11		4.68 (3.57–6.12)
Benzoxaboroles	DNDI-6148	1	2.10 (1.70–2.60)	7.25 (6.00–8.77)	12.35 (8.51–17.92)	2.36 (1.79–3.12)	18.26 (9.58–34.80)	2.04	180.70
		2	1.20 (0.61–2.33)	6.54 (4.17–10.25)		<1.11		<1.11
Aminopyrazoles	DNDI-1044	1	0.63 (0.56–0.72)	0.83 (0.78–0.89)	0.29 (0.28–0.32)	<0.33	<0.33	<1.11	48.89
		2	<1.11	<1.11		<1.11		<1.11
	DNDI-1047	1	0.24 (0.22–0.26)	0.34 (0.31–0.37)	<0.33	<0.33	<0.33	<1.11	>200
		2	<1.11	<1.11		<1.11		<1.11
	DNDI-8012	1	0.62 (0.58–0.67)	0.71 (0.61–0.84)	0.39 (0.38–0.41)	<0.33	<0.33	<1.11	>200
		2	<1.11	<1.11		<1.11		<1.11