Fig. 5.

Activity of topical liposomal AmB on the course of L. major lesion in BALB/c mice. Female BALB/c mice were SC inoculated at the base of the tail with stationary-phase L. major promastigotes (2 × 10⁶). At week 4 post-infection, lesions were measured and topically treated with 50 mg liposomal AmB formulations twice a day for 4 weeks. The lesion size was monitored by weekly measurement for 12 weeks. Values represent means ± standard errors of the means. The results for the Lip-AmB 0.1, 0.2 and 0.4-treated group of mice were significantly different from the control groups (mice receiving PBS or empty liposomes) (***, P<0.001).