Fig. 2.

Conformation of the CPT pocket. CPT structure is shown as a cyan surface and, around them, the different regions that interact with the terpenylquinones have been highlighted. Region A, residues between Ala177 and Lys200, is shown as green cartoon. Region B includes Thr217 and Asn221, which are shown as blue sticks. Region C, residues between Met250 and Pro257, is shown as yellow cartoon. Region D is formed by the residues Lys352 and Asp353, that are shown as pink sticks. It should be noticed that all these residues belong to the large subunit of LTop1B, but Thr217 and Asn221 belong to the small subunit. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)