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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct 31;1865(1):158544. doi: 10.1016/j.bbalip.2019.158544

Table 1:

ER-endosome interacting proteins

ER Protein Endo-lysosomal proteins Function Reference
VAPA ORP1L (late endosome) Cholesterol sensing, endosome positioning [25, 27]
VAPA/B STARD3 / STARD3NL (late endosome) Cholesterol sensing, endosome positioning [23, 24]
VAPA/B SNX2 (early and late endosome) Budding dynamics and lipid modifications [119]
Protrudin & VAPA Rab7 & PtdIns(3)P (late endosome) Endosome positioning [33]
VPS13C ? ER-endosome tethering and lipid transport [118]
S100A11 Annexin A1 (early and late endosomes) Receptor dephosphorylation and ILV formation [26]
ORP5 NPC1 (late endosome) Cholesterol transfer [28]
PTP1B EGFR and other RTKs, G-CSFR and ESCRT-0 proteins HRS and STAM2 (early and late endosome/MVB) Receptor dephosphorylation [26, 34–36, 123]
M1 Spastin IST1 (early and late endosome/MVB) Endosome fission [30, 39]
TMCC1 Coronin 1C (early and late endosomes) Endosome fission [31]
M0SPD2 STARD3 (late endosome) ER-endosome tethering [120]
M0SPD2 STARD3NL (late endosome) ER-endosome tethering [120]
M0SPD2 ORP1L (late endosome) ER-endosome tethering [120]