Table 2:

ER-Endo/Lysosomal MCS Localized Proteins Linked to Human Diseases

MCS Protein	Localization	Associated Disease	Reference
M1 Spastin	ER	HSP	[38, 150]
Protrudin	ER	HSP	[38, 150]
Strumpellin	ER	HSP	[38, 94, 95, 150]
VAPB	ER	ALS	[107]
NPC1	Late endosomes	Niemann-Pick disease, type C1 (lysosome storage disease)	[28, 155]
Annexin A1	Early and late endosomes	Cancer	[156]
VPS35	Early and late endosomes	Parkinson’s Disease	[92][93]
VPS13C	MCSs of ER-late endosomes/lysosomes and lipid droplets	Parkinson’s Disease	[117, 118]