Fig 4.

Contributions of subgroups to the proportion of food allergy cases in the SIG. A,Bar charts provide prevalence calculations used to estimate the reduction in total allergy burden and number needed to treat. Per-protocol adherence rates are shown for those EIG participants whose adherence rates were evaluable and also as a proportion of the whole EIG (percentages in parentheses). B, An 80% treatment effect and 85% adherence across all risk factors for allergy is assumed. For example, infants in EAT with visible eczema comprised 61.9% of the total food allergy burden. Hypothetically, if per-protocol adherence could be achieved in 85% of this subgroup, then 52.6% (61.9%*85%) of the allergic burden would experience the intervention. Moreover, if an intervention effect of 80% is assumed, then the total reduction in food allergy that would be realized from intervening on this subgroup would be 42.1% (52.6%*80%).