Table I.
Enrollment sensitization data from the EAT study
| Any food | Peanut | Egg | Milk | Sesame | Fish | Wheat | |
|---|---|---|---|---|---|---|---|
| SPT >0 mm | |||||||
| EIG | 5.1% (33/652) | 1.2% (8/652) | 3.7% (24/652) | 1.4% (9/652) | 0% (0/652) | 0.2% (1/652) | 0.2% (1/652) |
| EIG per-protocol | 4.0% (9/223) | 0.3% (1/336) | 2.6% (6/234) | 0.4% (2/451)† | 0% (0/288) | 0% (0/318) | 0% (0/216) |
| EIG non–per-protocol | 4.0% (12/302) | 1.9% (4/211) | 4.4% (14/315) | 4.9% (4/82) | 0% (0/262) | 0% (0/225) | 0% (0/336) |
| EIG adherence nonevaluable | 4.2% (5/120) | 1.0% (1/103) | 2.0% (2/101) | 0% (0/115) | 0% (0/102) | 0% (0/109) | 0% (0/99) |
| Specific IgE ≥0.1 kU/L | |||||||
| All participants | 15.6% (182/1170) | 3.6% (42/1166) | 6.7% (78/1170) | 6.0% (70/1169) | 2.0% (23/1151) | 0% (0/1164) | 4.3% (50/1165) |
| SIG | 15.4% (89/577) | 3.1% (18/576) | 7.3% (42/577) | 6.6% (38/576) | 1.4% (8/572) | 0% (0/575) | 4.3% (25/576) |
| EIG | 15.7% (93/593) | 4.1% (24/590) | 6.1% (36/593) | 5.4% (32/593) | 2.6% (15/579) | 0% (0/589) | 4.2% (25/589) |
| EIG per-protocol | 13.6% (28/206) | 2.3% (7/305)∗ | 3.3% (7/214)∗ | 3.9% (16/414) | 2.3% (6/263) | 0% (0/289) | 5.5% (11/201) |
| EIG non–Per-protocol | 15.4% (42/273) | 5.7% (11/193) | 8.0% (23/287) | 8.3% (6/72) | 3.1% (7/227) | 0% (0/204) | 3.7% (11/301) |
| EIG adherence nonevaluable | 15.0% (16/107) | 4.4% (4/90) | 4.4% (4/90) | 5.8% (6/103) | 2.3% (2/89) | 0% (0/96) | 2.3% (2/86) |
| Specific IgE ≥0.35 kU/L | |||||||
| All participants | 6.4% (74/1170) | 1.6% (19/1166) | 3.9% (45/1170) | 2.8% (33/1169) | 0% (0/1151) | 0% (0/1164) | 0.9% (10/1165) |
| SIG | 6.9% (40/577) | 1.6% (9/576) | 4.7% (27/577) | 3.3% (19/576) | 0% (0/572) | 0% (0/575) | 0.7% (4/576) |
| EIG | 5.7% (34/593) | 1.7% (10/590) | 3.0% (18/593) | 2.4% (14/593) | 0% (0/579) | 0% (0/589) | 1.0% (6/589) |
| EIG per-protocol | 2.9% (6/206) | 0% (0/305)∗ | 1.4% (3/214) | 0.7% (3/414)∗ | 0% (0/263) | 0% (0/289) | 0.5% (1/201) |
| EIG non–per-protocol | 5.1% (14/273) | 2.1% (4/193) | 3.8% (11/287) | 5.6% (4/72) | 0% (0/227) | 0% (0/204) | 1.3% (4/301) |
| EIG adherence nonevaluable | 6.5% (7/107) | 4.4% (4/90) | 2.2% (2/90) | 2.9% (3/103) | 0% (0/89) | 0% (0/96) | 0% (0/86) |
Rows showing the EIG divided into the per-protocol, non–per-protocol, and adherence nonevaluable subgroups show overall adherence status for the any food column and food-specific adherence status for individual food columns. Specific IgE levels were measured in 1170 children. However, some infants had very small amounts of serum obtained, and all 6 individual foods could not be measured. Hence the denominator for individual foods varies (ranging from n = 1151 for sesame to n = 1170 for egg). The 7 EIG participants who had positive enrollment challenge results to a food are excluded from the adherence rows (4 to milk, 1 to wheat, 2 to peanut, and 2 to egg) because they were unable to be adherent being already allergic to the food.
SPT, Skin prick test.
P < .05 and †P < .01, P values for the EIG per-protocol and EIG non–per-protocol groups.