Table 2.
Muscle fiber capillarization and muscle hypertrophy indices Pre- and Post-Intervention, grouped by basal CFPE index.
| LOW | HIGH | |||
|---|---|---|---|---|
| Pre-RET | Post-RET | Pre-RET | Post-RET | |
| Capillaries/mm2 | 296.93±75.31 | 345.24±124.25 | 334.37±72.77 | 318.00±103.36 |
| Capillaries per fiber (C:Fi) | 0.78±0.18 | 1.08±0.41* | 1.70±0.37# | 1.57±0.30 |
| Fiber type I | 0.94±0.08 | 1.20±0.15* | 1.87±0.11# | 1.69±0.16 |
| Fiber type II | 0.68±0.05‡ | 0.98±0.10‡* | 1.35±0.12‡# | 1.42±0.10 |
| CFPE index (capillaries/1000um) | 3.50±0.73 | 4.34±0.69* | 6.39±1.15# | 5.88±1.62 |
| Fiber type I | 3.87±0.15 | 4.76±0.22* | 6.80±0.32# | 6.55±0.84 |
| Fiber type II | 3.24±0.28‡ | 4.10±0.24* | 5.61±0.35‡# | 5.33±0.38 |
| LC-PF index (%) | 9.67±0.83 | 12.74±0.89* | 18.25±1.25# | 15.99±1.08 |
| Fiber type I | 11.94±0.87 | 14.25±0.99 | 20.27±1.53# | 16.93±0.84 |
| Fiber type II | 8.18±0.96‡ | 11.74±0.80* | 15.74±1.18‡# | 15.76±1.34 |
| Capillary contact (CC) | 2.25±0.53 | 2.99±0.85 | 4.53±0.82# | 4.10±0.54 |
| Fiber type I | 2.70±0.20 | 3.33±0.29* | 4.93±0.23# | 4.28±0.24 |
| Fiber type II | 1.95±0.15‡ | 2.71±0.22*‡ | 3.71±0.32*‡# | 3.89±0.17 |
| Fiber area (um2) | 3686.14±385.83 | 3965.16±604.04 | 3751.52±515.02 | 4697.06±562.41 |
| Fiber type I | 4455.80±514.89 | 4288.11±813.58 | 4244.50±596.18 | 5156.71±620.22 |
| Fiber type II | 3135.73±407.36‡ | 3428.26±526.17 | 3081.22±536.43‡ | 4131.36±557.05‡* |
Note: Values are means ± SE. CFPE, capillary-to-fiber perimeter exchange; HIGH, relative high baseline CFPE index; ASM, appendicular skeletal muscle; SMI, skeletal muscle index (ASM/height2); CSA, cross sectional area; FSR, fractional synthetic rate. N=9; LOW, relative low baseline CFPE index; N=10.
*
significantly different from pre-RET (p<0.05).
#
significantly different compared to LOW group (p<0.05).
‡
significantly different compared to type I fibers (p<0.05).