Table 4.
Differences in pathway activities scored per cell by GSVA between HNC tumor and normal tissues.
| Kegg pathway | logFC | AveExpr | t | P Value | adj.P.Val | B |
|---|---|---|---|---|---|---|
| HALLMARK_APICAL_JUNCTION | −0.4025 | 0.010961 | −5.25587 | 2.32E-07 | 6.26E-06 | 6.544336 |
| HALLMARK_HEME_METABOLISM | −0.28374 | −0.00808 | −4.51909 | 8.03E-06 | 0.000108 | 3.184278 |
| HALLMARK_XENOBIOTIC_METABOLISM | −0.43824 | 0.012682 | −4.39633 | 1.39E-05 | 0.000125 | 2.668925 |
| HALLMARK_KRAS_SIGNALING_DN | 0.238528 | 0.025281 | 4.240365 | 2.73E-05 | 0.000184 | 2.032894 |
| HALLMARK_ALLOGRAFT_REJECTION | 0.213846 | 0.003377 | 4.134352 | 4.28E-05 | 0.000231 | 1.612623 |
| HALLMARK_TNFA_SIGNALING_VIA_NFKB | −0.22983 | −0.01298 | −3.52174 | 0.000474 | 0.001829 | −0.6217 |
| HALLMARK_KRAS_SIGNALING_UP | −0.18953 | 0.007866 | −3.36564 | 0.000832 | 0.002807 | −1.13723 |
| HALLMARK_FATTY_ACID_METABOLISM | −0.30329 | 0.013411 | −3.11011 | 0.001994 | 0.005981 | −1.93318 |
| HALLMARK_INTERFERON_GAMMA_RESPONSE | 0.175599 | 0.015616 | 2.771092 | 0.005828 | 0.015735 | −2.89629 |
| HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION | −0.22674 | 0.017215 | −2.18466 | 0.02945 | 0.06824 | −4.30808 |
| HALLMARK_IL2_STAT5_SIGNALING | 0.116782 | 0.007269 | 2.17291 | 0.030329 | 0.06824 | −4.33303 |
| HALLMARK_APICAL_SURFACE | 0.182865 | 0.000551 | 2.049396 | 0.041026 | 0.085208 | −4.58742 |
| HALLMARK_SPERMATOGENESIS | −0.13185 | 0.012642 | −1.90605 | 0.057306 | 0.110518 | −4.86433 |
| HALLMARK_ESTROGEN_RESPONSE_EARLY | −0.19236 | 0.023794 | −1.72959 | 0.084417 | 0.15195 | −5.1781 |
| HALLMARK_PEROXISOME | 0.132034 | 0.017083 | 1.48572 | 0.138082 | 0.233013 | −5.56224 |
| HALLMARK_WNT_BETA_CATENIN_SIGNALING | 0.139712 | −0.01358 | 1.427229 | 0.154235 | 0.239908 | −5.6458 |
| HALLMARK_P53_PATHWAY | 0.118958 | −0.00521 | 1.407697 | 0.159939 | 0.239908 | −5.67296 |
| HALLMARK_GLYCOLYSIS | 0.12231 | −0.02451 | 1.114532 | 0.26567 | 0.362097 | −6.03604 |
| HALLMARK_ANDROGEN_RESPONSE | −0.09161 | −0.01368 | −1.08559 | 0.278264 | 0.362097 | −6.06734 |
| HALLMARK_INFLAMMATORY_RESPONSE | −0.05291 | 0.00149 | −1.07801 | 0.281631 | 0.362097 | −6.0754 |
| HALLMARK_COMPLEMENT | −0.05119 | 0.006593 | −0.93414 | 0.35075 | 0.41205 | −6.21774 |
| HALLMARK_ESTROGEN_RESPONSE_LATE | −0.09946 | 0.007701 | −0.93365 | 0.351006 | 0.41205 | −6.2182 |
| HALLMARK_REACTIVE_OXIGEN_SPECIES_PATHWAY | 0.068331 | −0.02072 | 0.803555 | 0.422095 | 0.474857 | −6.32939 |
| HALLMARK_ANGIOGENESIS | −0.06601 | 0.01222 | −0.76906 | 0.442275 | 0.477657 | −6.35609 |
| HALLMARK_MYOGENESIS | −0.06866 | −0.02249 | −0.62445 | 0.532663 | 0.55315 | −6.4553 |
| HALLMARK_NOTCH_SIGNALING | −0.05143 | −0.02244 | −0.5239 | 0.600614 | 0.600614 | −6.51217 |