Table 1.
Summary of LRF/ZBTB7A functions in cancer. The protein is notorious for exerting tissue- and context-dependent oncogenic or oncosuppressive functions, through multiple molecular interactions
| Cancer | Function | Molecular partners | Biological process | Reference |
|---|---|---|---|---|
| Lymphoma | Oncogenic | BCL6‚ p19Arf | Cell transformation, cell growth | 38 |
| Acute myeloid leukemia | Oncogenic | RUNX1/RUNX1T1 | Proliferation | 39 |
| Lung cancer | Oncogenic | miR-125a, miR-520e | Cell cycle, cell growth, proliferation, apoptosis, invasion | 40-43, 69, 85 |
| Oncosuppressive | HP1γ, AXL, PVT1, ELK1 | Proliferation, migration | 88 | |
| Hepatocellular carcinoma | Oncogenic | miR-125, miR-137, MEF2D, p53, p21,p27, cyclins, CDKs, PI3K/AKT, RAS/RAF/MEK/ERK, BCL2, FAS receptor, FADD, caspase-8, caspase-10 | Cell cycle, proliferation, apoptosis, migration/metastasis, invasion | 37, 44-48, 65, 66 |
| Oncosuppressive | miR-106b | Proliferation, apoptosis | 83 | |
| Prostate cancer | Oncogenic | STRN4, EGF | Proliferation, apoptosis | 49, 50, 79 |
| Oncosuppressive | Sox9, AR | Senescence, proliferation, invasion | 89, 92 | |
| Ovarian cancer | Oncogenic | MT1-MMP | Migration/metastasis, invasion | 51 |
| Breast cancer | Oncogenic | Survivin, SP1,Smad4 | Proliferation, apoptosis | 52-55, 77 |
| Gastric cancer | Oncogenic | C/EBPα/ miR-100 | Proliferation, migration/metastasis | 55 |
| Oncosuppressive | Not defined | Cell cycle, apoptosis, migration/metastasis | 95 | |
| Glioma | Oncogenic | AKT, cyclins, CDKs, NF-κB, Survivin | Cell cycle, proliferation, apoptosis, migration/metastasis | 56 |
| Sarcoma/mesenchymal tumors | Oncogenic | p21, p53, miR-663a, LncRNA GAS5, circular RNA of LRF/ZBTB7A - ILF2/3 | Cell cycle, proliferation, apoptosis, migration/metastasis, invasion, angiogenesis | 57, 58, 68, 103 |
| Oncosuppressive | DLK1, Sox9 | Cell transformation, proliferation | 93, 103 | |
| Colorectal cancer | Oncogenic | DAP5/p53, ETS-1 | Cell cycle, proliferation, apoptosis, migration/metastasis, invasion | 59-62 |
| Renal carcinoma | Oncogenic | miR-137 | Proliferation, invasion | 63 |
| Liver cancer | Oncogenic | miR-21, Sprouty1 | Cell growth, proliferation | 84 |
| Bladder cancer | Oncogenic | TGF-β | Cell growth, migration/metastasis, invasion | 81 |
| Melanoma | Oncosuppressive | MCAM | Migration/metastasis | 96 |