Table 6.
Comparison of ECV by selected baseline variables.
| Variables | ECV Mean ± SD | Unadjusted p value | Bonferroni adjusted p value |
|---|---|---|---|
| Age (years) | 0.391 | 1.000 | |
| ≤ 40(n = 417) | 0.29 ± 0.04 | ||
| 41–64 (n = 1537) | 0.29 ± 0.05 | ||
| ≥ 65 (n = 58) | 0.30 ± 0.06 | ||
| BMI (kg/m2) | < 0.001 | 0.001 | |
| ≤ 25 (n = 485) | 0.30 ± 0.05 | ||
| 26–30 (n = 772) | 0.29 ± 0.04 | ||
| ≥ 31 (n = 752) | 0.29 ± 0.05 | ||
| Gender | < 0.001 | 0.001 | |
| Male (n= 1417) | 0.28 ± 0.04 | ||
| Female (n = 596) | 0.31 ± 0.04 | ||
| Race | 0.546 | 1.000 | |
| Minority (n = 323) | 0.29 ± 0.05 | ||
| Non-minority (n = 1689) | 0.29 ± 0.05 | ||
| Family history of HCM | < 0.001 | 0.001 | |
| Yes (n = 683) | 0.29 ± 0.05 | ||
| No (n = 1322) | 0.30 ± 0.05 | ||
| LVOT gradient | 0.178 | 1.000 | |
| ≥ 30 mm Hg (n = 356) | 0.29 ± 0.05 | ||
| < 30 mm Hg (n = 1103) | 0.29 ± 0.05 | ||
| Maximal wall thickness (mm) | < 0.001 | 0.002 | |
| ≤ 20 (n = 1337) | 0.29 ± 0.04 | ||
| 21–29 (n = 411) | 0.30 ± 0.05 | ||
| ≥ 30 (n = 51) | 0.31 ± 0.05 | ||
| Arrhythmias | < 0.001 | 0.002 | |
| Yes (n = 368) | 0.30 ± 0.05 | ||
| No (n = 1639) | 0.29 ± 0.04 | ||
| Hypertension | 0.123 | 1.000 | |
| Yes (n = 718) | 0.29 ± 0.04 | ||
| No (n = 1289) | 0.29 ± 0.05 | ||
| LVEF < 55% | 0.005 | 0.055 | |
| Yes (n = 264) | 0.30 ± 0.05 | ||
| No (n = 1712) | 0.29 ± 0.04 | ||
| Genetics | < 0.001 | 0.001 | |
| Sarcomere mutation + (n = 706) | 0.30 ± 0.05 | ||
| Sarcomere mutation − (n = 1261) | 0.29 ± 0.05 |
ECV data are mean ± 1 Standard Deviation.
p values are from Kruskal-Wallis test and unadjusted for multiple testing. A Bonferroni correction would require a p value of < 0.0045 to declare statistical significance at a nominal Type I error rate of 0.05 (0.05/11).