Table 2.

Univariate and multivariate analyses of the associations between prognostic variables and overall and disease-free survival rates in epithelial ovarian cancer

	Overall survival hazard ratio [95% CI*], p-value		Disease-free survival hazard ratio [95% CI*], p-value
	Univariate	Multivariate	Univariate	Multivariate
FIGO stage (III-IV)	3.86 [1.52–9.82], 0.004	3.04 [1.15–8.04], 0.025	5.59 [2.79–11.20], < 0.001	4.98 [2.30–10.79], < 0.001
Cell type (serous)	3.43 [1.35–8.73], 0.009	2.24 [0.84–5.93], 0.105	3.19 [1.77–5.77], < 0.001	2.14 [1.00–4.58], 0.049
Tumor grade (poor)	1.79 [0.96–3.31], 0.064	NA	2.08 [1.34–3.23], 0.001	1.28 [0.77–2.11], 0.333
CA125+ (> 35 U/mL)	1.74 [0.62–4.89], 0.290	NA	1.92 [0.96–3.83], 0.064	NA
Age (> 50)	1.79 [0.96–3.35], 0.067	NA	1.34 [0.87–2.05], 0.173	NA
FOXO1 + a	2.74 [1.49–5.04], 0.001	2.77 [1.48–5.18], 0.001	1.79 [1.16–2.76], 0.008	1.71 [1.05–2.78], 0.029
PAX3 + b	2.17 [1.17–4.01], 0.013	1.56 [0.82–2.93], 0.168	1.62 [1.06–2.47], 0.025	1.00 [0.64–1.57], 0.980
FOXO1+/PAX3+	5.53 [2.47–12.40], < 0.001	4.60 [2.00–10.55], < 0.001	2.75 [1.47–5.15], 0.001	1.84 [0.97–3.50], 0.061

CI^† Confidence interval; NA Not applicable

^aCut-off value of FOXO1⁺ was over 137 of IHC score; ^bcut-off of PAX3⁺ was over 156 of IHC score; *CI Confidence interval, FIGO International Federation of Gynecology and Obstetrics, LN Lymph node; NA Not applicable