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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Biochem Pharmacol. 2019 Oct 9;170:113661. doi: 10.1016/j.bcp.2019.113661

Fig. 5. Comparison of experimental kinetics and modeling predictions for P450 catalyzed terbinafine N-dealkylations.

Fig. 5.

Modeling predictions compared to experimental kinetic parameters based on prediction scores (0–1.0) and kinetic efficiencies (Vmax/Km) scaled to fractional values. Fractional values were calculated based on predictions and efficiencies for metabolic split ratios of pathways within each individual P450. N-methyl-1-naphthyl methylamine, N-desmethyl-terbinafine, and 1-napthaldehyde were markers for the initial reactions of Pathways 1, 2, and 3, respectively. The graphs illustrate the calculated fractional values listed in Table 4. nd = no metabolite detected