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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Biochem Pharmacol. 2019 Oct 9;170:113661. doi: 10.1016/j.bcp.2019.113661

Fig. 8. Relative P450 involvement in N-dealkylation pathways of terbinafine.

Fig. 8.

P450 isozymes contributing to reaction steps of each terbinafine N-dealkylation pathway have been identified and scaled based on reaction efficiency and relative abundance in human liver microsomes to model contributions in adult human liver conditions. Higher contributions for individual isozymes relative to others are indicated by larger font size and boldness for reactions in Pathway 1 (red), Pathway 2 (blue), and Pathway 3 (green).