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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Biochem Pharmacol. 2019 Oct 9;170:113661. doi: 10.1016/j.bcp.2019.113661

Table 4.

Split ratiosa for terbinafine initial N-dealkylation reactions by P450s based on experimental kinetic efficiencies and computational predictions.

Model Reaction Cytochrome P450 isozymes
1A2 2A6 2B6 2C8 2C9 2C19 2D6 2E1 3A4
Experimental Kinetic Efficiency 1.1 0.42 NDb 0.37 ND 0.10 0.04 0.26 ND 0.09
2.1 0.58 ND 0.63 1.00 0.90 0.44 0.74 ND 0.20
3.1 ND ND ND ND ND 0.52 ND ND 0.71
Computational Prediction 1.1 0.17 0.26 0.12 0.14 0.10 0.12 0.23 0.12 0.10
2.1 0.43 0.36 0.46 0.46 0.39 0.50 0.35 0.26 0.46
3.1 0.40 0.38 0.42 0.40 0.51 0.39 0.43 0.62 0.44
a

Split ratio values calculated as described previously (Barnette et al., 2018) (Davis et al., 2019).

b

ND = metabolite not detected