. Author manuscript; available in PMC: 2020 Dec 1.

Published in final edited form as: Biochem Pharmacol. 2019 Oct 9;170:113661. doi: 10.1016/j.bcp.2019.113661

Table 5.

Relative contributions of individual P450 isozymes to in vivo hepatic terbinafine clearance and/or bioactivation

Pathway	Substrate	Metabolite	Percent contributions of individual isozymes for each reaction^a
Pathway	Substrate	Metabolite	CYP1A2	CYP2B6	CYP2C8	CYP2C9	CYP2C19^b	CYP2D6	CYP3A4^b
1.1	terbinafine	N-methyl-1-naphthyl methylamine	7.75	2.63	-	23.0	5.48	2.36	58.8
2.1	terbinafine	desmethyl-terbinafine	2.39	1.01	3.22	49.1	13.3	1.48	29.4
2.2a	desmethyl-terbinafine	1-naphthyl-methylamine	-	14.2	11.0	30.1	5.82	-	38.8
2.2b	desmethyl-terbinafine	1-naphthaldehyde	-	2.64	9.61	4.44	3.58	-	79.7
3.1	terbinafine	1-naphthaldehyde	-	-	-	-	13.3	-	86.7

Calculations based on extrapolations of kinetic efficiencies and reported levels of P405 isozymes as described under Materials and Methods.

Contributions determined using catalytic efficiency values published previously (Davis et al., 2019).