Table 2.
Allelic frequency of msp-1 and msp-2 in uncomplicated and severe malaria patients in Gublak, North West, Ethiopia
| Allele | Uncomplicated malaria (n = 95) | Severe malaria (n = 23) | p-value* | ||||
|---|---|---|---|---|---|---|---|
| n (%) | Fragment size (bp) | No. of alleles | n (%) | Fragment size (bp) | No. of alleles | ||
| MSP-1 | |||||||
| K1 | 30 (31.6) | 110–350 | 10 | 2 (8.7) | 110–250 | 4 | |
| MAD20 | 7 (7.4) | 130–350 | 6 | 2 (8.7) | 150–300 | 4 | |
| RO33 | 13 (13.7) | 150–200 | 3 | 5 (21.7) | 150–200 | 3 | |
| Total | 65 (68.4) | 19 | 20 (86.9) | 11 | 0.015 | ||
| MSP-2 | |||||||
| FC27 | 31 (32.6) | 250–550 | 9 | 6 (26.1) | 250–500 | 7 | |
| IC/3D7 | 19 (20) | 300–700 | 13 | 7 (30.4) | 300–500 | 6 | |
| Total | 73 (76.8) | 22 | 22 (95.7) | 13 | 0.138 | ||
| Overall MOI | 2.0 | 3.0 | |||||
n number of positive individuals, MOI multiplicity of infection, total total number of fragments and distinct clones
* p-value calculated by Chi-square test