FIGURE 3.

Plot of the effect of increasing the omeprazole equivalent on triple therapies given for 14 days in the presence of increasing clarithromycin resistance. Very low-dose PPI such as 4.5 mg omeprazole equivalent is estimated to achieve an overall cure rate of approximately 90% with susceptible infections and 10% with PPI-amoxicillin (~1 gram bid). The cure rate improves to ≥95% as omeprazole equivalent dose is increased to 20 mg or greater. As the omeprazole equivalent dose is increased, the proportion cured in the clarithromycin resistant population also progressively improves and results in the “double-dose” phenomenon