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. 2019 Dec 4;10:2773. doi: 10.3389/fmicb.2019.02773

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Copyright © 2019 Bauer, Misslinger, Shadkchan, Dietl, Petzer, Orasch, Abt, Graessle, Osherov and Haas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Downregulation of rpdA causes avirulence. Mouse survival curves (Kaplan–Meier plot) following intranasal infection of cortisone-acetate immunocompromised mice (n = 10 animals/group) with (+) and without (–) 10% xylose in the drinking water. Comparison of survival curves for rpdA^xylP−xylose vs. wild type or rpdA^xylP +xylose using the log-rank test (Mantel-Cox) revealed significance at P < 0.0001.