Table 3.
Intra-individual changes in circulating biomarker levels between baseline and post-intervention time points
| Circulating Biomarker Levels* | mean measures (n=8) | baseline vs. month 6 | mean measures (n=8) | baseline vs. month 12 | ||
|---|---|---|---|---|---|---|
| baseline | month 6 | p-value* | baseline | month 12 | p-value* | |
| Adiponectin (ug/mL) | 8.7 | 9.9 | 0.09 | 8.7 | 9.6 | 0.19 |
| Cortisol (ng/mL) | 94.4 | 88.9 | 0.65 | 94.4 | 88.6 | 0.63 |
| IGF-1 (ng/mL) | 82.6 | 82.4 | 0.95 | 82.6 | 74.9 | 0.03 |
| IGFBP-3 (ug/mL) | 2.5 | 2.2 | 0.03 | 2.5 | 2.0 | 0.005 |
| Insulin (uU/mL) | 5.4 | 4.6 | 0.39 | 5.4 | 4.8 | 0.50 |
| Leptin (ng/mL) | 18.1 | 17.2 | 0.83 | 18.1 | 17.5 | 0.88 |
| Glucose (mg/dL) | 129.9 | 133.2 | 0.89 | 129.9 | 106.7 | 0.33 |
| CRP (mg/L) | 1.2 | 0.8 | 0.33 | 1.2 | 0.9 | 0.46 |
| IL-1B (pg/mL) | 26.3 | 28.0 | 0.46 | 26.3 | 20.8 | 0.02 |
| IL-2 (pg/mL) | 38.7 | 38.4 | 0.92 | 38.7 | 28.7 | 0.01 |
| IL-4 (pg/mL) | 33.6 | 36.5 | 0.37 | 33.6 | 26.5 | 0.03 |
| IL-5 (pg/mL) | 26.8 | 27.0 | 0.94 | 26.8 | 20.9 | 0.02 |
| IL-6 (pg/mL) | 58.2 | 60.8 | 0.93 | 58.2 | 77.1 | 0.54 |
| IL-8 (pg/mL) | 111.5 | 132.2 | 0.09 | 111.5 | 93.3 | 0.14 |
| IL-10 (pg/mL) | 57.6 | 58.4 | 0.90 | 57.6 | 40.7 | 0.03 |
| GM-CSF (pg/mL) | 32.7 | 35.4 | 0.39 | 32.7 | 26.1 | 0.05 |
| IFN-γ (pg/mL) | 44.0 | 49.3 | 0.15 | 44.0 | 36.3 | 0.05 |
| TNF-α (pg/mL) | 29.6 | 30.2 | 0.81 | 29.6 | 22.3 | 0.02 |
*
adjusted for BMI