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. 2019 Nov 30;23(Suppl 2):S93–101. doi: 10.5213/inj.1938218.109

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Copyright © 2019 Korean Continence Society

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 4. — Phosphorylated cyclic adenosine-3,5′-monophosphate (cAMP) response element-binding protein (p-CREB)/CREB ratio and cAMP expression under conditions of postoperative cognitive dysfunction (POCD) in human neuronal SH-SY5Y cells. Left panel: The relative expression of p-CREB and CREB determined by western blotting. Right panel: cAMP expression determined using enzyme-linked immunoassay. A, control group; B, POCD-induced group; C, POCD-induced and 4-μg/mL PDRN-treated group; D, POCD-induced and 8-μg/mL PDRN-treated group; E, POCD-induced and 16-μg/mL PDRN-treated group. ^*P<0.05 compared to the control group. ^#P<0.05 compared to the POCD-induced group.