TABLE 1.
Health Utilities and Medical Costs Used in the Simulation Model
| Parameter | Value | Source |
|---|---|---|
| Health utility weights (per year) | 28 | |
| Flare | 0.62 | |
| Remission | 0.89 | |
| Health care costs (per 8 week period) – 2016 USD | ||
| No flarea | 14, 15 | |
| Office Visit | $54.83 | |
| Blood work | $13.46 | |
| Total | $68.29 | |
| New flare (one-time costs) | 14, 15 | |
| Office Visit | $118.80 | |
| Blood and stool workb | $69.60 | |
| CT Scan | $265.02 | |
| Colonoscopy | $877.60 | |
| Surgical pathology | $39.70 | |
| Total | $1370.72 | |
| Continuing flare (per 8-week period) | 14, 15 | |
| Office visit (every 8 weeks) | $118.80 | |
| Blood workc | $21.46 | |
| Total | $140.26 | |
| IFX test cost (every 6 months) | $250.00 | 12 |
| IFX infusion cost | $82.22 | 15 |
| IFX drug cost (dose of 5 mg/kg for a 70 kg patient) | $1558.58 | 12 |
| IMM cost | $75.6 | 12 |
aAssuming 3 established office visits per year and routine blood work 4 times a year including complete blood count with differential, aspartate aminotransferase, alkaline phosphatase, and total bilirubin. Cost expressed as 8-week interval.
bCost of blood work to evaluate a new flare episode includes complete blood count with differential, C-reactive protein, erythrocyte sedimentation rate, and stool Clostridium difficile PCR testing.
cCosts of blood work to evaluate an ongoing flare includes complete blood count, C-reactive protein, and erythrocyte sedimentation rate
IMM: immunomodulatory—azathioprine 2 mg/kg used for costing estimates