Table 2.

List of in vivo studies and tested parameters

Year/author	Species	Age/weight	Sample size	Teeth	Cavity	Material	Treatment	Duration	Risk of bias
2013 Azimi et al.[29]	Human	12–16 years	12	24 upper and lower premolars	Class 1	`iRoot BP -ProRoot MTA	Partial pulpotomy	6 weeks	Low
2014 Zhu et al.[22]	Wistar rats	220 g	20	Upper 1st molars	Class V mesial surface	iRoot BP Plus -MTA	DPC	28 days	Low
2014 Nicholson[30]	Human	7–58 years	41	According to the case	According to the case	-EERM -ProRoot MTA -Biodentine	Vital pulp therapy	160– 1000 days	Moderate
2015 Liu et al.[9]	Wistar rats	180–200 g	20	24 upper 1st molars	Class V Mesial surface	iRoot BP Plus MTA	DPC/pulpotomy	1 and 4 weeks	Low
2015 Zhang et al.[23]	Rats	-	-	Maxillary segment	_	iRoot BP Plus -ProRoot MTA	_	28 days	Low
2016 Shi et al.[31]	Beagle dogs	8 months	3	36 upper and lower incisors	Class V Labial surfaces	iRoot BP Plus -MTA	DPC	3 months	Moderate
2016 Anujalkhur[32]	Human	19–28 years	5	15 upper and lower premolars	Class 1	ERRM -MTA -GIC	DPC	3 weeks	Low
2018 Okamoto et al.[33]	Wistar rats	180–200 g	10	20 upper first molars	Class 1	-iRoot BP Plus -ProRoot MTA	DPC	2–4 weeks	Low

ERRM = EndoSequence root repair material, MTA = mineral trioxide aggregate, GMTA = gray mineral trioxide aggregate, WMTA = white mineral trioxide aggregate, UBP = ultra-blend Plus, GIC = glass–ionomer cement, IRM = intermediate restoration material, DPC = direct pulp capping