Table 3.
Results of cytotoxicity tests of included studies
| Author | Materials | Cells | Significant results | Significant level (P value) |
|---|---|---|---|---|
| Ma et al.[16] | ERRM putty ERRM paste GMTA IRM Cavit G |
Human gingival fibroblast | IRM, Cavit G > ERRM Putty, MTA, ERRM paste |
P < 0.001 |
| Damas et al.[17] | RRM ERRM putty ProRoot MTA MTA Angelus |
Human dermal fibroblast | RRP > ProRoot MTA, MTA Angelus, RRM |
P < 0.01 |
| Hirschman et al.[18] | ERRM Putty MTA Angelus UBP Dycal |
Human dermal fibroblast | Materials > Control (8 days) | P < 0.05 |
| De-Deus et al.[7] | iRoot BP Plus ProRoot MTA |
Human osteoblast | IRoot BP Plus > ProRoot MTA (48 h) |
P < 0.001 |
| Liu et al.[9] | IRoot BP Plus MTA | Human dental pulp cells | MTA > iRoot BP Plus (1 and 3 days) | P < 0.05 |
| Chen et al.[25] | ERRM ProRoot MTA | -Human bone marrow- derived mesenchymal stem cells -Periodontal ligament stem cells -Dental pulp stem cells |
Control, MTA > ERRM (day 3) | P < 0.05 |
| Coaguila- Llerena et al.[26] |
ERRM Putty MTA Angelus Super EBA |
Human periodontal ligament fibroblast |
Super EBA> ERRM > MTA (whole time) |
P < 0.05 |
| Martínez- Cortés et al.[27] | ERRM White MTA Angelus IRM |
Human gingival fibroblast | IRM > MTA > ERRM | |
| Sultana et al.[28] | ERRM ProRoot MTA Biodentine |
Human bone marrow- derived mesenchymal cells | Biodentine > ProRoot MTA > ERRM (day 7) |
P = 0.0003 |
| Zhang et al.[10] | iRoot BP Plus MTA Bioaggregate |
Human dental pulp cells | -MTA > IRoot BP Plus, Bioaggregate (day 1) -iRoot BP Plus, Bioaggregate > MTA (day 3, 5, 7) |
P < 0.01 |
| Willershausen et al.[20] | ERRM GMTA White MTA Angelus ProRoot MTA |
Human periodontal ligament fibroblasts and osteoblast | MTAs > ERRM (whole time osteoblast) and 24 for human periodontal ligament fibroblasts | P < 0.001 |
| Zhu et al.[22] | iRoot BP Plus ProRoot MTA |
Human dental pulp stem cells | No significant difference between the two materials | _ |
| Samyuktha et al.[21] | ERRM MTA Biodentine |
Human periodontal ligament fibroblasts | Control > materials | P < 0.05 |
| Öncel Torun et al.[8] | iRoot BP white MTA |
Human dental pulp cells | White MTA > IRoot BP (after 48 h) | P < 0.05 |
ERRM = EndoSequence root repair material, MTA = mineral trioxide aggregate, GMTA = gray mineral trioxide aggregate, WMTA = white mineral trioxide aggregate, UBP = ultra-blend Plus, GIC = glass–ionomer cement, IRM = intermediate restoration material, DPC = direct pulp capping