Table 2.
Increase of neuropeptides in neurons after axotomy
| Neuropeptide | Mechanism of injury | Location of measurement | References |
|---|---|---|---|
| CGRP | Spinal nerve transection | DRG | Nitzan-Luques et al., 2013 |
| SN transection | DRG | Fu et al., 2013 | |
| SN crush/transection | MN | Calderó et al., 1992 | |
| SP | Spinal nerve transection | DRG | Nitzan-Luques et al., 2013 |
| SN CCI | DRG | Da et al., 2017 | |
| SN transection | VH | Zhang et al., 1993 | |
| VIP | SN transection | DRG | Villar et al., 1989 |
| SN transection | DRG/DH | Shehab et al., 1986 | |
| SN CCI | DRG | Nahin et al., 1994 | |
| SN transection | MN | Zignond et al., 1996 | |
| SST | SN ligation and dorsal rhizotomy | DRG | Shi et al., 2014 |
| SN transection | MN | Zhang et al., 1993 | |
| GAL | SN transection | DRG/DH | Villar et al., 1989 |
| SN CCI | DRG | Nahin et al., 1994 | |
| SN transection | MN | Zhang et al., 1993 | |
| NPY | SN transection | DRG | Wakisaka et al., 1991 |
| SN transection | DH | Wakisaka et al., 1991 | |
| SN CCI | DRG | Nahin et al., 1994 | |
| SN ligation/crush | DRG | Wakisaka et al., 1991 | |
| Spinal nerve ligation | DRG | Fukuoka et al., 2015 |
All injuries were performed in adult rats. The changes indicated are mainly based on the studies of mRNA expression or immunoreactivity. Measurements were performed in sensory neurons of the dorsal root ganglia (DRG) or motoneurons (MN) in the spinal cord; in some cases, determinations were described as expression in the dorsal horn (DH) or ventral horn (VH). Note that for each molecule, the references are grouped according to the type of injury, as in some cases the expression varies depending on the injury model or cell type. CCI: Chronic constriction injury; CGRP: calcitonin gene related peptide; FN: facial nerve; GAL: galanin; NPY: neuropeptide tyrosine; SN: sciatic nerve; SP: substance P; SST: somatostatin; VIP: vasoactive intestinal peptide.