Figure 6.

Functional characterization of astrocyte-converted neurons in the grey matter and white matter of mice.

(A) Brain slice recordings in the cortical area showing repetitive action potentials and robust spontaneous synaptic events in NeuroD1-converted neurons. (B) Brain slice recordings in the striatal area showing different action potential firing pattern and moderate synaptic events in NeuroD1-converted neurons. (C) Brain slice recordings in the corpus callosum showing that the majority of NeuroD1-converted neurons in the white matter did not fire action potentials and the spontaneous synaptic events were also rarely recorded. Red arrowheads indicate miniature postsynaptic events. EPSC: Excitatory postsynaptic currents; IPSC: inhibitory postsynaptic currents; NeuroD1: neurogenic differentiation 1.