Skip to main content
. 2019 Dec 11;2019(12):CD006281. doi: 10.1002/14651858.CD006281.pub5

Comparison 1. Nusinersen versus placebo.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Acquisition of head control 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
2 Acquisition of the ability to sit independently 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
3 Acquisition of the ability to stand 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
4 Acquisition of the ability to roll 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
5 Motor milestone response on the Hammersmith Infant Neurological Examination‐Section 2 (HINE‐2) (final analysis) 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
6 Motor milestone response on the Hammersmith Infant Neurological Examination‐Section 2 (HINE‐2) (interim analysis) 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
7 Response on the Children’s Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND) (final analysis) 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
8 Adverse events 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
9 Severe adverse events 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only