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. Author manuscript; available in PMC: 2019 Dec 11.
Published in final edited form as: ACS Chem Biol. 2018 Jun 11;13(8):2190–2202. doi: 10.1021/acschembio.8b00349

Figure 4.

Figure 4.

Activity of compounds 1, 5, and 6 against ex vivo parasites. Compounds were added to cultures of A. adult worms and B. schistosomula, and worm survival was followed by monitoring worm movement. Compounds 1 (♦), 5 (■), and 6 (•) were tested at 50 μM against adult worms and 10 μM against schistosomula; control, untreated worms (▲). C. TGR activity in treated worms. Worms were cultured in the presence of 50 μM of 5 (■) or 6 (•). At the indicated times worms were collected and tested for residual TrxR activity (closed symbols) or GR activity (open symbols). All worms were alive when collected. Activity is expressed as compared to carrier (DMSO) alone treated worms cultured ex vivo for the same length of time.