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. 2019 Dec 4;10:1245. doi: 10.3389/fgene.2019.01245

Figure 3.

Figure 3

Fitness genes overlapping with prognostic genes and differentially expressed genes (DEGs) in colon adenocarcinoma (COAD). Fitness genes were defined as genes required for cell growth or viability (Behan et al., 2019). Genome-scale CRISPR-Cas9 knockout (GeCKO) screening results mining showed fitness genes (green scatters) in COAD cells with microsatellite instability (MSI), including RKO (A), SW48 (B), and KM12 (C), as well as COAD cells with microsatellite stability (MSS), such as SW837 (D), HT55 (E), and MDST8 (F). A total of 12 upregulated and one downregulated genes were discovered to overlap with prognostic and fitness genes (G).