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. 2019 Dec 4;10:1245. doi: 10.3389/fgene.2019.01245

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Copyright © 2019 Hu, Fu, Si, Li, Sun, Du and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The essential genes across pan-cancer. Dependency scores of CCT6A (A), UTP18 (B), YRDC (C), RRP12 (D), RFT1 (E), NLE1 (F), and DDOST (G) across pan-cancer based on GeCKO screening data by DepMap web portal (https://depmap.org/portal/depmap). The CERES dependency score is based on data from a cell depletion assay. A lower CERES score indicates a higher likelihood that the gene of interest is essential in a given cell line. A score of 0 indicates a gene is not essential; correspondingly, −1 is comparable to the median of all pan-essential genes (red line). The color and size of circles represent mutation and expression, respectively.