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. 2019 Dec 3;11:326. doi: 10.3389/fnagi.2019.00326

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Copyright © 2019 Xue, Guo, Gao, Wang, Cui, Chen, Wang and Xiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differences in directed functional connectivity from the right hippocampus to the whole brain and from the whole brain to the right hippocampus between each pair of groups. Panel (A) represents the comparison between the MCI and NC groups, panel (B) represents the comparison between the AD and NC groups, and panel (C) represents the comparison between the AD and MCI groups. The red line denotes that the GCA value in the former group was higher than the latter group, and the blue line denotes that the GCA value in the former group was lower than the latter group. The solid line indicates the directed functional connectivity from the hippocampus to other brain regions, and the dashed line indicates the directed functional connectivity from other brain regions to the hippocampus.