TABLE 2.

Directed functional connectivity showing significant differences in the left hippocampus and the whole brain pairwise comparisons.

Brain region	Abbreviation	Peak coordinate (MNI)			T-score	Cluster size (voxels)
		X	Y	Z
Left HIP to the whole brain
NC vs. MCI
Right inferior temporal gyrus	ITG.R	48	−45	−24	−3.3837	109
Left inferior temporal gyrus	ITG.L	−54	−45	−21	4.4304	245
Right middle temporal gyrus	MTG.R	45	3	−27	−4.2429	117
Right parahippocampal gyrus	PHG.R	21	−3	−27	−3.0788	122
Left inferior frontal gyrus, triangular portion	IFGtriang.L	−42	24	3	−3.17	98
Left anterior cingulate and paracingulate gyri	ACG.L	−6	36	15	4.2995	119
Right inferior frontal gyrus, triangular portion	IFGtriang.R	54	33	15	3.0303	144
Left middle frontal gyrus	MFG.L	−45	12	51	−3.5591	91
Right superior frontal gyrus	SFG.R	18	6	63	−3.8702	90
NC vs. AD
Right temporal pole: superior temporal gyrus	TPOsup.R	42	3	−27	−3.9766	173
Left inferior temporal gyrus	ITG.L	−54	−57	−24	4.0115	481
Right caudate nucleus	CAU.R	6	9	6	−3.6686	121
Right posterior cingulate gyrus	PCG.R	12	−39	27	−3.1048	162
Right superior frontal gyrus	SFG.R	15	36	33	−3.8617	388
Left precuneus	PCUN.L	−9	−63	63	4.443	259
MCI vs. AD
Left temporal pole: superior temporal gyrus	TPOsup.L	−27	3	−33	−3.2968	121
Right insula	INS.R	39	0	−12	−3.6394	115
Right cerebellum_6	Cereb.R	39	−57	−24	4.079	161
Left middle occipital gyrus	MOG.L	−30	−96	−6	3.077	91
Right thalamus	THA.R	6	−15	6	3.1359	87
Right rolandic operculum	ROL.R	48	0	6	−3.1668	97
Left anterior cingulate and paracingulate gyri	ACG.L	−6	18	24	−4.2899	1419
Left superior frontal gyrus	SFG.L	−15	54	15	−3.2588	180
Whole brain to the left HIP
NC vs. MCI
Right inferior temporal gyrus	ITG.R	60	−42	−18	3.251	108
Right inferior frontal gyrus, orbital portion	ORBinf.R	45	36	−12	3.5497	93
Left superior frontal gyrus, medial	SFGmed.L	−6	42	21	−3.6127	203
Right supplementary motor area	SMA.R	9	0	63	3.424	139
NC vs. AD
Left cerebellum_9	Cereb.L	−9	−57	−57	−3.513	163
Left cerebellum_Crus2	Cereb.L	−48	−69	−39	−3.2864	91
Right cerebellum_6	Cereb.R	21	−60	−21	−3.6537	253
Left cerebellum_6	Cereb.L	−15	−66	−15	−3.9553	200
Left inferior temporal gyrus	ITG.L	−60	−12	−33	−4.1771	114
Right inferior frontal gyrus, triangular portion	IFGtriang.R	48	30	27	4.6348	914
Right caudate nucleus	CAU.R	6	6	6	4.0654	99
Right superior frontal gyrus	SFG.R	24	9	57	3.5079	185
MCI vs. AD
Left cerebellum_Crus2	Cerebe_Crus2.L	−27	−78	−57	−3.6233	98
Left cerebellum_Crus1	Cerebe_Crus1.L	−21	−75	−24	−3.8854	684
Left anterior cingulate and paracingulate gyri	ACG.L	−6	24	18	3.6713	263
Left superior frontal gyrus	SFG.L	−24	51	0	3.2931	91
Right caudate nucleus	CAU.R	3	6	6	3.6922	195
Left inferior frontal gyrus, triangular portion	IFGtriang.L	−45	15	6	3.6202	158
Right inferior frontal gyrus, triangular portion	IFGtriang.R	51	36	15	4.3022	672