TABLE 3.

Directed functional connectivity showing significant differences in the right hippocampus and the whole brain pairwise comparisons.

Brain region	Abbreviation	Peak coordinate (MNI)			T-score	Cluster size (voxels)
		X	Y	Z
Right HIP to the whole brain
NC vs. MCI
Right lenticular nucleus, pallidum	PAL.R	−6	−21	−24	−3.5274	237
Left calcarine fissure and surrounding cortex	CAL.L	−9	−90	−6	3.2123	223
Right middle frontal gyrus	MFG.R	36	60	3	3.0021	154
Left paracentral lobule	PCL.L	−6	−33	51	−3.4208	113
NC vs. AD
Left Vermis_10	Vermis_10. L	−3	−42	−36	−3.4724	134
Right insula	INS.R	39	−18	3	−5.1014	433
Left inferior frontal gyrus, triangular portion	IFGtriang.L	−36	36	0	3.1908	92
Left superior temporal gyrus	STG.L	−54	−24	6	−3.6128	153
Right middle frontal gyrus	MFG.R	39	51	15	3.708	116
Right median cingulate and paracingulate gyri	DCG.R	3	−24	30	3.7886	195
Left precentral gyrus	PreCG.L	−51	0	33	4.3147	91
Left inferior parietal, but supramarginal and angular gyri	IPL.L	−30	−75	48	3.1726	99
Right precuneus	PCUN.R	12	−63	63	3.6249	137
MCI vs. AD
Right Heschl gyrus	HES.R	39	−21	6	−3.4666	327
Right fusiform gyrus	FFG.R	36	−63	−15	3.3393	112
Left insula	INS.L	−27	21	−12	−4.0594	106
Left inferior frontal gyrus, triangular portion	IFGtriang.L	−36	36	0	3.5881	140
Right caudate nucleus	CAU.R	6	6	−3	−3.4331	94
Left caudate nucleus	CAU.L	−9	9	18	−3.8284	464
Left superior temporal gyrus	STG.L	−45	−27	9	−3.8611	107
Right median cingulate and paracingulate gyri	DCG.R	24	−42	42	4.0994	379
Right precuneus	PCUN.R	15	−78	48	4.1331	696
Whole brain to the right HIP
NC vs. MCI
Right cerebellum_Crus2	Cerebe_Crus2.R	9	−87	−42	−3.6594	103
NC vs. AD
Right cerebellum_Crus2	Cerebe_Crus2.R	18	−78	−57	−3.0899	107
Right Heschl gyrus	HES.R	42	−21	9	3.9572	313
Left middle temporal gyrus	MTG.L	−45	−48	18	−3.4141	173
Right calcarine fissure and surrounding cortex	CAL.R	12	−63	9	3.874	284
Left anterior cingulate and paracingulate gyri	ACG.L	−6	27	15	3.949	107
Left middle frontal gyrus	MFG.L	−30	24	51	−4.9485	434
Right superior occipital gyrus	SOG.R	24	−69	39	−3.2264	93
MCI vs. AD
Right insula	INS.R	39	0	−9	3.8809	394
Left anterior cingulate and paracingulate gyri	ACG.L	−18	33	18	3.4111	107
Left superior temporal gyrus	STG.L	−36	−42	21	−3.8151	148
Right inferior frontal gyrus, opercular portion	IFGoperc.R	60	15	27	3.1223	89
Right precuneus	PCUN.R	18	−75	45	−3.2829	173
Left middle frontal gyrus	MFG.L	−33	24	51	−3.5317	86
Right paracentral lobule	PCL.R	6	−21	78	−3.8933	142