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Representative m/z plots of HDX time courses of (A) wild type, (B) H49A, and (C) H299N in the absence of ligands on peptide 51–58. Deconvolution of the bimodal peak (blue) reveals a lower-mass envelope (green) that represents a closed state and a higher-mass envelope (red) that represents the open state. H49A and H49N are fully deuterated within 3 min, which is significantly faster than the wild type, which is still not fully exchanged by 30 min.
