. Author manuscript; available in PMC: 2019 Dec 11.

Published in final edited form as: Trends Mol Med. 2010 Nov 17;17(2):88–96. doi: 10.1016/j.molmed.2010.10.009

Table 1.

Structure and kinase selectivity of clinically advanced CHK1 inhibitors.

Inhibitor	CHK1 IC₅₀ (nM)	CHK2 IC₅₀ (nM)	CDK1 IC₅₀ (nM)	CDK2 IC₅₀ (nM)	PKC IC₅₀ (nM)
UCN-01	11	1040	31	30	7
AZD7762	5	<10	>5000	>500	>500
PF477736	0.49	47	9900	-	-
SCH900776	3	1500	-	160	-