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A model of barrier disruption and skin sensitization. Allergens, infections, and tissue damage can stimulate release of TSLP, IL-33, and IL-25 from the epithelium. These epithelial cell–derived cytokines license dendritic cells (DCs) to drive type 2 responses but also act on a variety of cell types, including basophils, eosinophils, MCs, and innate lymphoid cells, to initiate and maintain allergic inflammation.128
