| Toxicity(1) | |||||
| Study | Toxicity | TopotecanGrade 1, 2 n(%) | TopotecanGrade 3, 4 n(%) | Topotecan/thalidomideGrade 1, 2 n(%) | Topotecan/thalidomideGrade 3, 4 n(%) |
| Downs 2008 | Neutropenia | 3(8) | 28(72) | 1(3) | 26(87) |
| Thrombocytopenia | 14(36) | 14(36) | 19(63) | 6(20) | |
| Anemia | 20(51) | 9(23) | 21(70) | 4(13) | |
| Auditory/hearing | 0 | 0 | 3(10) | 0 | |
| Cardiovascular | 0 | 0 | 2(7) | 0 | |
| Constitutional | 20(51) | 2(5) | 18(60) | 2(7) | |
| Dermatology | 6(15) | 0 | 5(17) | 1(3) | |
| Endocrine | 2(5) | 0 | 1(3) | 0 | |
| Gastrointestinal | 15(38) | 4(10) | 12(40) | 1(3) | |
| Genitourinary | 2(5) | 1(3) | 0 | 0 | |
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