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. 2019 May 15;68(8):1635–1648. doi: 10.2337/db18-1178

Figure 1.

Figure 1

Aggf1 is required for essential functions of EPCs in capillary tube formation, proliferation, TEM, and migration as in a diabetic mouse model (db/db mice). EPCs were isolated from bone marrow of WT, heterozygous Aggf1+/− KO mice, db/db mice, and Aggf1+/−db/db mice and characterized. A: Aggf1 haploinsufficiency inhibits angiogenesis mediated by EPCs. B: Images from panel A were analyzed, quantified, and plotted. C: Aggf1 haploinsufficiency inhibits EPC proliferation. D: Aggf1 haploinsufficiency inhibits TEM of EPCs in transwell assays. E: Images from panel D were quantified and plotted. F: Aggf1 haploinsufficiency inhibits EPC migration in scratch wound migration assays. G: Representative images from EPC migration assays. Data are mean ± SD. *P < 0.05, **P < 0.01 (n = 6 mice/group).