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. Author manuscript; available in PMC: 2019 Dec 11.
Published in final edited form as: Cell Rep. 2019 Nov 26;29(9):2875–2889.e6. doi: 10.1016/j.celrep.2019.10.100

Figure 5. Inhibiting MCs during SE Reduces the Severity of Chronic Seizures (Epilepsy).

Figure 5.

(A) Timeline highlighting the chronic period of epilepsy, when the data in the figure were taken. At 4 weeks after SE, mice were recorded with vEEG for 2 consecutive weeks to quantify spontaneous convulsive seizures.

(B1) The total number of seizures was lower in iDREADDs mice compared to Cre−/−.

(B2) Seizure frequency (seizures/day) was lower in iDREADDs mice.

(B3) The number of days where at least one seizure was detected was lower in iDREADDs mice.

(B4) The number of consecutive days with a seizure was lower in iDREADDs mice.

(B5) The duration of convulsive seizures in iDREADDs mice was significantly shorter than Cre−/− mice.

(C1a and C2a) Representative EEG recording.

(C1b and C2b) Spectrogram corresponding to the EEG shows a convulsive seizure in a Cre−/− mouse compared to a convulsive seizure in an iDREADDs mouse. Note that the convulsive seizure in the Cre−/− mouse is considerably longer than the iDREADDs mouse (arrows). Data are represented as mean ± SEM. *p < 0.05.