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. Author manuscript; available in PMC: 2019 Dec 11.
Published in final edited form as: Science. 2018 Aug 17;361(6403):709–712. doi: 10.1126/science.aas9963

Figure 1. Fmr1 is specifically required during the storage of mature, quiescent stage 14 oocytes in the ovary.

Figure 1.

(A) Schematic of a Drosophila ovariole with immature pre-checkpoint follicles and two stored mature stage 14 follicles. (B) Plot shows arrested mature follicle stability (red) following feeding protocol as described (Supplemental). (C) Fmr1 knockdown (line #1 and line #2), but not knockdowns of controls or other indicated genes, specifically reduces 10-day stored (red) but not 1-day stored (black) oocytes from developing into hatching larvae. (D) Fmr1 germline RNAi during storage progressively reduces the fraction of mature oocytes competent after 1, 4, 7 or 10 days of storage to support development. Re-feeding females to promote maturation of fresh stage 8 follicles restores full developmental potential.