Fig. 17.2.
Olanzapine (oral administration, 8 mg/kg) and metabolite distribution at 2 h post-dose in a whole-rat sagittal tissue section monitored by imaging MS. Organs are outlined in red on the photomicrograph of the section (a). MS/MS ion images of olanzapine (b) and its N-desmethyl (c) and 2-hydroxymethyl (d) metabolites are displayed. (Adapted from Ref. (2) with permission.)
