Figure 6.

Adaptive optics scanning light ophthalmoscopy (AOSLO) of P2. (A) Confocal AOSLO photoreceptor mosaic scaled and superimposed on an FAF image. A central dark atrophic region was imaged, revealing a lack of waveguiding properties. The white square marks the 200-μm square in greater magnification in (B). (B) Confocal imaging and (C) split-detection image over the same location. The top right corner lacks waveguiding properties on (B) and ambiguous cellular structures (blue arrow heads, remnant inner segments) are seen on split-detection (C). A few cones at the edge of the lesion have greater preserved reflectivity, and inner segments on split-detection and are marked with yellow arrowheads. Scale bar for (A), 1000 μm; and for (B, C), 100 μm