Table 1. Characteristics of the study population.
NA, not applicable.
| Characteristic |
Participants with RNA sequencing and actigraphy |
Participants with RNA sequencing and cognitive assessment |
Participants with immunohistochemistry for microglia and actigraphy |
| Number | 152 | 621 | 156 |
| Age at last visit (years) | 88.7 [85.9, 92.6] | 87.8 [83.6, 92.1] | 88.5 [85.5, 92.1] |
| Age at death (years) | 89.6 [86.6, 93.3] | 89.0 [84.8, 93.1] | 89.4 [86.3, 92.9] |
| Female sex | 102 (67.1%) | 396 (63.8%) | 105 (67.3%) |
| European descent | 150 (98.7%) | 611 (98.4%) | 153 (98.1%) |
| Years of education | 14.0 [12.0, 16.0] | 16.0 [14.0, 18.0] | 14.0 [12.0, 16.0] |
| Mini Mental State Examination Score | 25.5 [19.1, 28.0] | 25.0 [18.0, 28.0] | 27.3 [24.8, 28.5] |
| Composite global cognition | −0.62 [−1.41, −0.01] | −0.67 [−1.55, −0.06] | −0.48 [−1.24, 0.05] |
| Clinical diagnosis AD | 51 (33.6%) | 246 (39.6%) | 45 (28.8%) |
| Time from last cognitive assessment to death (years) |
0.7 [0.4, 1.0] | 0.7 [0.4, 1.0] | 0.7 [0.4, 1.1] |
| Average sleep fragmentation (kRA) | 0.027 [0.024, 0.032] | NA | 0.027 [0.025, 0.032] |
| Number of actigraphy recordings | 2.0 [1.0, 3.0] | NA | 2.0 [1.0, 39.0] |
| Time from last actigraphy to death (years) |
1.3 [0.6, 2.3] | NA | 1.4 [0.6, 2.5] |
| Postmortem interval (years) | 6.3 [5.1, 7.8] | 5.9 [4.4, 8.4] | 6.4 [5.2,8.3] |
| AD pathology summary score | 0.58 [0.18, 1.00] | 0.56 [0.16, 1.03] | 0.56 [0.17,0.97] |
| NIA-Reagan pathological AD (intermediate/high) |
96 (63.2%) | 375 (60.4%) | 93 (59.6%) |
| Presence of Lewy body pathology | 33 (21.7%) n = 147 | 125 (20.1%) n = 599 | 34 (21.8%) n = 149 |
| Macroscopic infarcts present | 21 (13.8%) | 76 (12.2%) | 23 (14.7%) |
| Microscopic infarcts present | 30 (19.7%) | 96 (15.5%) | 22 (14.1%) |
| Extralimbic TDP-43 pathology | 83 (54.6%) n = 150 | 269 (43.3%) n = 533 | 86 (55.1%) n = 155 |
| Presence of hippocampal sclerosis | 12 (7.9%) | 45 (7.2%) n = 616 | 13 (8.3%) |
| Density of microglia | 190.8 [150.4, 225.6] | 182.4 [141.4, 217.0] | 191.1 [144.0, 237.9] |
| % Stage I microglia | 95.9 [94.0, 98.3] | 95.9 [94.0, 98.4] | 95.8 [93.9, 98.4] |
| % Stage II microglia | 3.8 [2.0, 5.0] | 3.8 [2.3, 5.1] | 3.9 [2.3, 5.2] |
| % Stage III microglia | 1.3 [0.9, 1.9] | 1.5 [1.0, 2.3] | 1.4 [1.0, 2.1] |