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. 2019 Dec 11;5(12):eaax8898. doi: 10.1126/sciadv.aax8898

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Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 6 — (A) Top: Differential genes expressed in Sox2^high, Sox9^high, and Cdx2^high human stomach cancer (STAD) transcriptomes are compared to our E16.5 GI RNA-seq profiles. Bottom: Gene set enrichment analysis reveals strong associations between Sox2^high/Sox9^high cancer genes and the E16.5 stomach profiles and between Cdx2^high cancer genes and the E16.5 intestinal profiles. (B) Similar analysis conducted using human colon cancer (COAD) transcriptomes from TCGA shows the activation of stomach and intestinal lineage-specific genes in Sox2^high/Sox9^high and Cdx2^high cancers, respectively.