Extended Data Figure 5: Dorsally patterned forebrain organoids show reproducibility similar to that of endogenous brain, as compared to self-patterned whole-brain organoids.

a-b, Percent distribution of cell types in a, (left) individual 3 month PGP1 (two batches: b1, b2) and HUES66 (n=3 per batch) dorsally patterned forebrain organoids, and (right) individual 6 month 11a, GM08330, and PGP1 (two batches: b1, b3, n=3 per batch) dorsally patterned forebrain organoids, vs. b, individual 6 month self-patterned whole-brain organoids³. c-e, Distribution of cell types as assigned in the original publication across c, individual samples of fetal human cortex²⁹, d, adult human cortex samples from distinct individuals²⁸, and e, adult mouse cortex samples from distinct individuals³⁰. Abbreviations as in Fig. 1. DG, dentate gyrus; CGE, caudal ganglionic eminence; MGE, medial ganglionic eminence.