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. 2019 Dec 10;476(23):3649–3660. doi: 10.1042/BCJ20190779

Figure 2. TauA in complex with different alkanesulfonate analogues.

Figure 2.

(A–C) Calorimetric titration taurine binding to TauA and alkanesulfonate derivatives (see also Table 2). Each peak (top panel) represents an injection of 2.4 µl of taurine into 200 µl of TauA. The bottom panel shows the integrated heat obtained from the raw data, after subtracting the heat of dilution. Binding of 2-AEP (A) and MES (B) to TauA is endothermic whereas binding of ACES (C) is exothermic. (D–F) Close up views of TauA in complex with the alkanesulfonate analogues 2-AEP (D), ACES (E) and MES (F). All compounds show similar interactions to taurine with the exception of 2-AEP that requires Ser131 to adopt a different rotamer to co-ordinate the smaller phosphonate group. The colour scheme is the same as in Figure 1; the phosphate group of 2-AEP is shown in cyan.