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. 2019 Dec 10;476(23):3649–3660. doi: 10.1042/BCJ20190779

Table 1. Thermodynamic parameters for taurine binding to TauA and mutants.

Kd (nM) Stoichiometry  ΔH (kJ/mol) ΔS (J/mol/K)
WT 1.6 0.768(±0.38%) −61.04 (±0.08%) −3.05
Gln30Ala 3480 0.83(±6%) −17.87 (±8%) 3.72
Asp106Ala NB NB NB NB
Thr132Ala 20 620 0.8* −28.76 (±8%) −0.54
Asp205Ala 22 880 0.8* −34.83 (±2%) −2.34

NB, no binding.

*

Stoichiometry fixed to 0.8 during data fitting.