Table 2.

Linear combination giving the highest cross-validated AUC.

Patient category	N	No. positive (% Sensitivity) [95% CI]	Cutoff value	GCV-AUC	Coefficients
					IgM						IgG
					BmpA	FlaB	OspC	BBA65	BBA70	BBA73	DbpA	FlaB	OspC	VlsE	BBA69	BBA73
Early Lyme EM Acute	40	28 (70) [55–82]	0.94	0.97		0.23	−0.18	−0.29	0.09	−0.16	0.11	0.49	0.42	0.61	−0.01	0.02
Early Lyme EM Convalescent	38	33 (87) [73–94]	1.03	0.96	−0.11	0.06	0.14	−0.34		0.03		0.43		0.79	−0.15	−0.03
Carditis	7	7 (100) [65–100]	0.65	1.00	0.10	−0.08	0.54		−0.26		0.56	0.25		0.49
Neuroborreliosis	9	9 (100) [70–100]	0.08	1.00		0.64	0.61	−0.25	−0.31	0.22					0.06	−0.02
Non-Lyme disease		No. positive (% Specificity a) [95% CI]
Healthy non-endemic	102	1 (99) [65–100]

^aSpecificity based on early Lyme EM acute linear combination and cutoff.